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Bilevel optimization and multicriteria approximations: application to computational protein design
1 : Unité de Mathématiques et Informatique Appliquées de Toulouse
Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement : UR0875
2 : Unité de Mathématiques et Informatique Appliquées de Toulouse
Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement : UR0875
In this presentation, we present the computational protein design
problem and its extensions to multistate negative design. The single
state design can be modelled as a pure discrete optimization problem.
The multistate negative design is a more challenging problem that
requires either bilevel or bicreteria optimization depending on the
energy model. We explored both directions and present some preliminary
results.
